Sara "Pez" Pezzini searches for justice which brings her into contact with the Witchblade. An ancient, intelligent, living weapon so powerful it can battle Earth's darkest evil forces. Week in and week out, Pez employs her skills as a police detective to fight crime.

Pez finds she must employ the Witchblade to combat a much greater and frighteningly organized conspiracy of evil that threatens the very soul of humanity.