Colt .45 is an American Western series which aired on ABC between October 1957 and September 1960. Christopher Colt was apparently a gun salesman but was in fact a government agent tracking down notorious bad guys.

The half-hour program is loosely based on the 1950 Warner Bros. film of the same name, starring Randolph Scott. Colt .45 was part of the William T. Orr-produced array of westerns which Warner produced for ABC in the late 1950s and early 1960s.