The series is set in China during the reign of the Yongzheng Emperor of the Manchu-led Qing dynasty. The emperor orders Nalan Degang, a Manchu bannerman, to form and lead a secret death squad to eliminate the Great Ming Society, a Yangzhou-based underground movement seeking to overthrow the Qing dynasty and restore the Ming dynasty. The death squad is named "Flying Guillotines" after the highly dreaded weapon used by its members.